Try this:
Close the BlackBerry Desktop Manager application.
Disconnect the BlackBerry device from the computer.
Double Click on My Computer> Local Disk (C drive>Documents and Settings>(username)>Application Data>Research In Motion>Blackberry>Intellisync
Note: If the Application Data folder is not present, click Tools>Folder Options at the top of the screen.
Click the View Tab, then click on Show Hidden Files and Folders.
Click Apply>Ok and continue through the remaining steps.
Delete everything within the Intellisync folder.
Launch BlackBerry Desktop Manager and attempt sync the device with the computer.
